We all first fell in love with Patrick Dempsey as the adorable nerd in Can't Buy Me Love, and now we love the more mature, sexy Dr. Derek Shepherd on Grey's Anatomy. He just seems like the most down-to-earth, non-Hollywood, family man, who really seems to appreciate all that he has. In the current issue of US Weekly he dishes about falling in love, expecting twins and loving his fans. Here's more:

No wonder more than 25 million fans tuned in to the third season premiere on September 21, when McDreamy professed his love for his intern, Meredith Grey (Ellen Pompeo). “Patrick has always been an incredibly down-to-earth, kind person,” Debra Messing, his onetime Will & Grace costar, tells Us. “He has been around for a long time and has his head on his shoulders. I could not be more thrilled for him.”

Dempsey’s offscreen life is also booming. He and his wife of seven years, celebrity makeup artist and former hairstylist Jillian Dempsey, 40, are expecting twin boys. (The couple have a daughter, Tallulah, 4.) “I’m really thrilled,” Patrick said on Ryan Seacrest’s L.A. radio show September 20. “My wife looks great, we're excited, my daughter’s happy and we’re going to have a very big family very soon.”

For a guy who went from geek to chic and the famous ups and downs in Hollywood, we're happy to see him back on top. A little JCrew modeling in between didn't hurt. We love that US Weekly put this sexy man on their latest cover. Lots more pics of Patrick just doing some everyday shopping at Whole Foods, and his pregnant wife and little girl so read more

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