Seth Rogen's cancer comedy 50/50 is a project close to home for the actor, since it's the real life story of his good friend Will Reiser's battle with the disease. We sat down with Seth at the Toronto Film Festival, the morning after the big premiere earned a standing ovation from the audience. No one was more surprised than Seth, who joked that he expects failure. Seth also shared which scene from the movie was word-for-word an actual incident he and Will went through and which scene he had the most fun shooting. Check out our interview and see 50/50 when it hits theaters on Friday.