Will 2010 be your best year ever? It can be. I'm a big fan of stepping out of the proverbial box to try new things. No risk, no reward. Start by taking care of yourself, whether you try an out-of-the-ordinary nail polish or decide to invest in skin care. I've rounded up some favorites, with picks from $3 to $200 — so you'll find something whether you're watching every penny or itching to use that gift card you got over the holidays. Happy perusing!