I still think of Seth Rogen as a raunchy comedy guy, but in Funny People he showed that he can pull off understated comedy as well. In 50/50, he's revisiting the subject of a friend with cancer, only this time, he's coming from a place of personal experience. Based on his friend Will Reiser's cancer diagnosis at the age of 27, the film is produced by Rogen and written by Reiser. Rogen also stars as Kyle, the best friend of Adam (the character based on Reiser), who is played by Joseph Gordon-Levitt. We see him go from a healthy young man who's shocked to find out he has a tumor to someone battling illness and its physical and mental repercussions. Adam has help in the form of his supportive and yes, funny, friend Kyle and a youthful therapist played by Anna Kendrick.
Despite the delicate theme, it looks like Rogen and co. have hit just the right balance; it seems funny but restrained, and objective about Adam's diagnosis while neither downplaying it nor manipulating the audience. I think Gordon-Levitt was the perfect casting choice for Adam, since the actor has the chops for a meaty role like this, and he's able to play straight man to Rogen's sense of humor. Watch the trailer for 50/50 when you read more.