According to Wikipedia (so, you know, grains of salt required), Rice did not initially like the idea of Tom Cruise in the role of Lestat. She reportedly said that Cruise was "'no more my Vampire Lestat than Edward G. Robinson is Rhett Butler' and the casting was 'so bizarre, it's almost impossible to imagine how it's going to work.' Nevertheless, she was satisfied with Cruise's performance after seeing the completed film, saying that 'from the moment he appeared, Tom was Lestat for me' and 'That Tom did make Lestat work was something I could not see in a crystal ball.'" If the RDJ thing ends up being true, I wonder what Rice will think of this casting choice. Personally, I think it's inspired. I'd love to see him in this role!
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