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Dallas Buyers Club

Matthew McConaughey's performance as AIDS-afflicted '80s cowboy Ron Woodroof is stunning. His weight loss is just a small part of his disappearance into the role, which has McConaughey transform into a hard-living, homophobic, shady man-about-town who turns desperate but never pitiful in his fight against a disease (and the FDA's arbitrary laws), which was still quite new to the world at the time. And Jared Leto is exceptional as Ron's cross-dressing business partner, who helps Ron distribute unapproved AIDS treatments to other patients. It's not just the fact that he's almost unrecognizable; Leto is truly heartbreaking at points.

Image Source: Focus Features