Along with Seth Rogen and Jason Segel, James Franco became a Hollywood heavyweight after appearing on the teen comedy-drama Freaks and Geeks. The show was canceled in 2000 after only 12 episodes but became a cult classic and launched many of its stars to TV and movie fame. Franco has gone on to become a jack of all trades, starring in films like 127 Hours, Milk, Spring Breakers, and the original Spider-Man trilogy. Don't forget that he also had a random recurring role on General Hospital, all while attending Yale, teaching at NYU, and hosting the 2011 Oscars. Does he ever get tired?