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anniepemas anniepemas 7 years
There are many offspring of older dad who suffer genetic disorders due to the paternal age effect. Paternal age effect From Wikipedia, the free encyclopedia Jump to: navigation, search The paternal age effect describes the influence that a father's age has on the chances of conferring a genetic defect to his offspring. Generally, older men have a greater probability of fathering children with a genetic defect than younger men do. This is seen as likely due to genetic copying errors which may increase in number after repeated spermatogenesis cycles over a man's lifetime. [edit] Disorders correlated with paternal age Achondroplasia (dwarfism); craniofacial disorders such as Apert syndrome and Crouzon Syndrome; mental retardation of unknown etiologies; autism; bipolar disorder; and 25% of schizophrenia cases are correlated with advanced paternal age. Other disorders related to advanced paternal age are: Wilms' tumor Thanatophoric dysplasia Retinitis pigmentosa Osteogenesis imperfecta type IIA Acrodysostosis Fibrodysplasia ossificans progressiva Aniridia Bilateral retinoblastoma Multiple exostoses Marfan syndrome Lesch-Nyhan syndrome Pfeiffer syndrome Wardenburg syndrome Treacher Collins syndrome Soto's basal cell nevus Cleidocranial dysostosis Polyposis coli Oculodentodigital syndrome Costello syndrome Progeria Recklinghausen's neurofibromatosis Tuberous sclerosis Polycystic kidney disease Hemophilia A Duchenne muscular dystrophy Athetoid cerebral palsy Dystonic cerebral palsy Congenital hemiplegia Down syndrome Bipolar disorder [edit] References Crow JF (1997). "The high spontaneous mutation rate: Is it a health risk?". PNAS 94: 8380–6. doi:10.1073/pnas.94.16.8380. http://www.pnas.org/cgi/content/full/94/16/8380. Bertram L, Busch R, Spiegl M, Lautenschlager NT, Müller U, Kurz A (1998). "Paternal age is a risk factor for Alzheimer disease in the absence of a major gene". Neuroscience 1 (4): 277–80. doi:10.1007/s100480050041. http://www.springerlink.com/content/j2xvhj1r9c4vyh6h/. Sipos A, Rasmussen F, Harrison G, Tynelius P, Lewis G, Leon DA, Gunnell D (2004). "Paternal age and schizophrenia: a population based (sic) cohort study". BMJ Online 329: 1070. doi:10.1136/bmj.38243.672396.55. PMID 15501901. http://www.bmj.com/cgi/content/abstract/bmj.38243.672396.55v1. "DNA repair activity linked to paternal age effect". University of Texas Health Science Center at San Antonio. 2000-08-28. http://www.uthscsa.edu/opa/issues/new33-32/graduate.htm. Bray I, Gunnell D, Smith GD (2006). "Advanced paternal age: How old is too old?". Journal of Epidemiology and Community Health 60: 851–3. doi:10.1136/jech.2005.045179. http://jech.bmj.com/cgi/content/abstract/60/10/851. Montgomery SM, Lambe M, Tomas O, Ekbom A (2004). "Paternal age, family size, and risk of multiple sclerosis" ([dead link]). Epidemiology 15 (6): 717–23. doi:10.1097/01.ede.0000142138.46167.69. http://www.epidem.com/pt/re/epidemiology/abstract.00001648-200411000-00011.htm;jsessionid=FTyPmJX2pQ0vndYv7JDFBhGxjJJcM6NbJ7XTtxh2LWfyx6nMnGGv!-2083468996!-949856145!8091!-1. Reichenberg A, Gross R, Weiser M, Bresnahan M, Silverman J, Harlap S, Rabinowitz J, Shulman C, Malaspina D, Lubin G, Knobler HY, Davidson M, Susser E (2006). "Advancing paternal age and autism". Archives of General Psychiatry 63 (9): 1026–32. doi:10.1001/archpsyc.63.9.1026. http://archpsyc.ama-assn.org/cgi/content/abstract/63/9/1026. Sanders L (2005). "College scientist named Ellison Senior Scholar". University of Southern California College of Letters, Arts & Sciences. http://www.usc.edu/schools/college/news/december_2005/arnheim.html. Fisch H, Hyun G, Golden R, Hensle TW, Olsson CA, Liberson GL (2003). "The influence of paternal age on down syndrome (sic)". J Urol 169 (6): 2275–8. doi:10.1097/01.ju.0000067958.36077.d8. PMID 12771769. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12771769&dopt=Abstract. Rami B, Schneider U, Imhof A, Waldhör T, Schober E (1999). "Risk factors for type I diabetes mellitus in children in Austria". Eur J Pediatr 158 (5): 362–6. doi:10.1007/s004310051092. PMID 10333115. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10333115&query_hl=22&itool=pubmed_docsum. Singh NP, Muller CH, Berger RE (2003). "Effects of age on DNA double-strand breaks and apoptosis in human sperm". Fertility and sterility 80 (6): 1420–30. doi:10.1016/j.fertnstert.2003.04.002. http://cat.inist.fr/?aModele=afficheN&cpsidt=15380275. Lauritsen MB, Pedersen CB, Mortensen PB (2005). "Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study". J Child Psychol Psychiatry 46 (9): 963–71. doi:10.1111/j.1469-7610.2004.00391.x. PMID 16108999. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16108999&query_hl=2&itool=pubmed_docsum. Wohl M, Gorwood P (2007). "Paternal ages below or above 35 years old are associated with a different risk of schizophrenia in the offspring". Eur Psychiatry 22 (1): 22–6. doi:10.1016/j.eurpsy.2006.08.007. PMID 17142012. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17142012&query_hl=13&itool=pubmed_docsum. "Schizophrenia Research Forum: Current Hypotheses". 2006-03-28. http://www.schizophreniaforum.org/for/curr/Malaspina/default.asp. Choi J-Y, Lee K-M, Park SK, Noh D-Y, Ahn S-H, Yoo K-Y, Kang D (2005). "Association of paternal age at birth and the risk of breast cancer in offspring: a case control study". BMC Cancer 5: 143. doi:10.1186/1471-2407-5-143. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291359. "NW Andrology & Cryobank". http://www.nwcryobank.com/donor_standards.html. Croen LA, Najjar DV, Fireman B, Grether JK (2007). "Maternal and paternal age and risk of autism spectrum disorders". Archives of Pediatrics and Adolescent Medicine 161 (4): 334–40. doi:10.1001/archpedi.161.4.334. http://archpedi.ama-assn.org/cgi/content/short/161/4/334. Tarin JJ, Brines J, Cano A (1998). "Long-term effects of delayed parenthood". Human Reproduction 13 (9): 2371–6. doi:10.1093/humrep/13.9.2371. http://humrep.oxfordjournals.org/cgi/reprint/13/9/2371. Sukanta Saha et al. (2009). "Advanced Paternal Age Is Associated with Impaired Neurocognitive Outcomes during Infancy and Childhood". PLoS Medicine 6: e40. doi:10.1371/journal.pmed.1000040.
runningesq runningesq 7 years
Selfish, IMO. You have a baby at 65.... and you may not live to see your kid graduate high school
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