First thing I do when I get to a hotel with my kids is have my husband take them exploring as I get everything in order. Nothing is worse than needing to change an explosive poopy diaper and having to dig through a suitcase to find diapers, wipes, diaper cream, etc. So, upon arrival, get yourself organized — I like to set up feeding and diapering stations so I have a go-to spot, just like at home. And put a sheet on the floor with toys if you've got an upright baby or crawler.
Source: Flickr user Lisa Sunde