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Jane Leeves

Shortly after Daphne Moon's marriage to Niles Crane, Jane Leeves became pregnant. Not wanting to add a baby to the Frasier storyline, the writers had her experience significant weight gain due to stress and eventually sent her character off to a fat camp at the end of her real-life pregnancy.

Source: NBC
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Jane Leeves' Character, Daphne, was not yet married to David Hyde Peirce's character, Niles when she went away to the "spa". Daphne was gaining so much weight due to her insecurities over her new relationship with Niles.