AnybodyOutThere, not to be confused with the old Pink Floyd song, is a topic-based chat platform that takes your topic of interest, which you plug in as a post of up to 110 characters, and spits out a list of other like-minded people also interested in discussing your topic or something closely related. All you have to do is pick someone from the list, click on the "Let's Talk" button and AnybodyOutThere opens up a chat dialog for you to begin your discussion.
The site is free, and you can post a topic or begin a chat as a guest, or sign in to take advantage of the site's ability to also match people not only on what they post, but by your demographics as well.
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