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Grey's Anatomy Rundown: Episode 22, "What a Difference a Day Makes" The 100th episode of Grey's has all the elements of a classic: there's a big tragedy, a few sweeping speeches, and a wedding that makes me cry despite lots of lapses of logic. It's not my favorite Grey's of the season, but if a measure of a good episode is whether I was a weepy mess by the end, then it's good.