Watch Patrick Dempsey Go From Quirky '80s Star to Silver Fox in 27 Photos

Patrick Dempsey [1] has been in the spotlight for more than 30 years now, but we still can't get over how handsome he is. The 50-year-old actor first stole hearts with his roles in movies like Can't Buy Me Love, Mobsters, and Loverboy, but it wasn't until he became Dr. Derek Shepherd on Grey's Anatomy [2] that our hearts really started pumping. Aside from his impressive acting career, Patrick is a devoted family man; he's been married to his wife, Jillian Fink [3], since 1999 (they briefly split [4] last year), and is father to kids Talula, Sullivan, and Darby. Cheers to many more years of being able to stare into those McDreamy eyes!