Meryl Streep took on the challenge of portraying British prime minister Margaret Thatcher in The Iron Lady, which she spent much of this year working on. It's a departure from her most recent comedy success in It's Complicated but could put her back into contention for another Oscar nod. Her break from comedy is short lived since Meryl is already in talks to star with funny lady Tina Fey as a neurotic mother-daughter duo in Mommy & Me.
72. Meryl Streep
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