Last season leaves off with Cersei unhappily taking the Iron Throne, but this isn't how the game will end. We know the prophecy of Maggy the Frog already predicted all of Cersei's children would die. Since that has happened, all that is left is the part of the prophecy where she will be killed by a little brother. The finale ends with Tyrion on his way back with Daenerys Targaryen, and Jaime giving Cersei a look while she is on the throne. He's probably not happy with her, since her revenge plot ends up with their last child committing suicide. Both brothers now have a reason to kill her, and those plans can start rolling next season.