The scene where the villains are at Happy's apartment with Peter and Aunt May includes a subtle nod to Dr. Octopus's love life in the Amazing Spider-Man comics. In No Way Home, Doc Ock and May have a brief conversation, during which she calls him "Mr. Octopus." What MCU fans unfamiliar with the comics may not know is that the two characters had a relationship in the comics and almost became Mr. and Mrs. Octopus.