In the comics, Uncle Ben tells Peter, "With great power, there must also come great responsibility." Marisa Tomei's Aunt May tragically echoes this line as she's dying in Peter's arms in No Way Home. We also hear a shortened version of his quote in the 2002 Spider-Man movie that goes, "With great power comes great responsibility," which gets referenced later on in No Way Home when all three Spider-Men are opening up about losing people they love. "She told me with great power . . . ," Holland's Peter starts. "Comes great responsibility," Maguire's Peter finishes.