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Caffeine + Tylenol = Not Good

A new study has shown that when high doses of caffeine and acetaminophen (such as Tylenol) are taken together, it could lead to liver damage. This combination produces a byproduct enzyme that can be toxic to the liver. Sounds a bit scary, I know. So read on for more details.

It requires more than just taking two Tylenol with your morning cup of coffee to create this toxic effect. It takes excessive amounts of caffeine to produce this reaction - we're talking about 20 cups of coffee! The bad news is that the combination of alcohol and acetaminophen can also damage your liver. So if you are ingesting high amounts of caffeine, acetaminophen, and alcohol, your liver could be at risk. Otherwise, for most people, you don't need to worry. It is interesting to note that many OTC painkillers, like those for migraines, do contain caffeine.

Source & Source

Join The Conversation
Hollisterbabe01 Hollisterbabe01 9 years
Thanks for the heads up! because i just took tylenol and a cup of tea!! i felt great after but i guess it is really bad for you!
Lovely_1 Lovely_1 9 years
I already thought this is true because I remember once taking a tylenol at work (that's all we have in out First Aid Kit) and I was drinking coffee too and wow I felt VERY pooky and gross and I ahven't done that since.
beingtazim beingtazim 9 years
i prefer ibiprofin (no idea how to spell it!). tylenol has always made me feel ill.
demeter demeter 9 years
Well that's good because I hate coffee, and would never take Tylenol with alcohol anyway.
amandaaa amandaaa 9 years
i've heard this a rumor before but now it's confirmed. at least it involves lots of caffeine.
pk9000 pk9000 9 years
Excedrin or a cup of coffee and a Tylenol will not cause the type of damage this article is referring to. You need a lot of caffeine to cause any damage. In the article, they mention 10 times as much as a few cups of coffee. Nonsteriodal anti-inflammatory drugs (ibuprofen, naproxen) are COX inhibitors just like aspirin. There's little risk of liver damage and they do not cause problems with alcohol like Tylenol. It's fine to take Advil or Aleve for a hangover. Tylenol causes liver damage because a toxic intermediate is produced as it is being metabolized. The enzyme that eliminates this intermediate is also used in alcohol metabolism. So, when you have alcohol in your system and you take acetaminophen (Tylenol) you get a build up of the toxic compound that causes liver damage.
The-Italian-Jem The-Italian-Jem 9 years
Tylenol, and to a lesser extent ibuprofen (advil) and naproxen (Aleve) can lead to liver failure if ingested while there is alcohol in the system (hangover!) Stick to aspirin, lots of water (and coffee, if necessary for that hangover). It's one of the oldest pain relievers and still works best!
janellethechef janellethechef 9 years
So, this means that having Tylenol and a cup of coffee for a hangover is a very bad idea? Do ibuprophen, asprin, and naproxen have similar adverse affects on the liver?
i_heart_me i_heart_me 9 years
Thanks for givin' us the skinny, FitSugar!
tati33 tati33 9 years
Thanks Fit! I heard about this on the news this morning but couldnt listen to which drug would interact caffeine. I agree for my migraines I take Excedrin..and it has a nice doese of caffeine but then again you can not exceed 2 pills in 24
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