Science Confirmed: Ultraprocessed Foods Cause Weight Gain — Here's What to Eat Instead

Keto, Paleo, low-carb, vegetarian, vegan — there are so many diets out there, almost all of them purporting weight loss benefits. Yet the one thing most diets have in common is the recommendation to avoid ultraprocessed foods. It's not an easy feat. You know how some people recommend sticking to the "sides" of the supermarkets (the produce, dairy, and meat sections)? That's because the vast majority of your average grocery store is taken up by boxes and bags of unhealthy, packaged, overprocessed foods. According to a 2016 study, almost 60 percent of the American diet is made up of these highly processed products.

Now, researchers have confirmed what's been long suspected but never proven: ultraprocessed foods, in and of themselves, drive weight gain. This might not sound revolutionary, mostly because past research has pointed out a correlation between the rise of obesity and the rise of ultraprocessed foods. But this study, conducted by the National Institutes of Health (NIH), proved that it's not only because processed foods have more sugar, salt, or fat. The researchers controlled for all of those, plus carbs, protein, fiber, sodium, and total calories offered.

What happened was maybe not totally unexpected: the ultraprocessed group gained weight. But the actual details are pretty staggering. Over just two weeks, a group of 10 people gained an average of two pounds per week eating the ultraprocessed foods. Another group, eating whole, unprocessed foods, lost the same amount.

Ultraprocessed Foods Made People Eat More and Feel Hungrier

The two groups were divided equally between men and women, and they all lived at the NIH facility for four weeks — the full duration of the study — to ensure complete control over their diets. Each group was given three meals a day, "designed to be well matched across diets for total calories, energy density, macronutrients, fiber, sugars, and sodium," the study said, and allowed to eat as much as they wanted. At the end of two weeks, the ultraprocessed group switched to an unprocessed diet, and vice versa.

On average, the ultraprocessed group ended up consuming 508 more calories per day, most of that coming from carbs and fat; participants ended up eating about the same amount of protein in both groups, which might support what's called the protein leverage hypothesis: that people will eat until they meet their protein needs. Despite eating more at meals (especially breakfast and lunch), the ultraprocessed group didn't rate their food as any tastier than the unprocessed group. They also tended to eat faster, which has been shown to result in higher calorie consumption.

Researchers also found that ultraprocessed food made participants feel hungrier at the hormonal level. PYY, known as an appetite-suppressing hormone, was higher in the unprocessed group, while the "hunger hormone" ghrelin was also lower in the unprocessed group.

What Are Ultraprocessed Foods?

It's worth reviewing the differences between unprocessed, processed, and ultraprocessed food products, because they're pretty big. The study used the classifications set by NOVA, a categorization system based on the amount of processing in foods.

  • Unprocessed foods: These are what they sound like: whole foods like fruit, vegetables, grains, legumes, nuts, meats, seafood, eggs, and milk.
  • Processed foods: Foods that have ingredients like oil, sugar, salt, or other processed ingredients added to them. These aren't necessarily unhealthy for you — they can include products like tofu, canned beans, and cheese — though they can be (think fruit submerged in sugary syrup).
  • Ultraprocessed foods: Foods that go through the most processing and have the longest ingredient lists, full of added and artificial ingredients. These include sodas, candy, and chips, but also foods we might think of as not as unhealthy, like cereals, packaged soups, and reconstituted meat such as sausage or fish sticks.

What Did They Eat?

The differences between the unprocessed and ultraprocessed meals are noticeable, but what's surprising is the fact that, at first glance, the ultraprocessed options don't seem that unhealthy. Take a look at one breakfast given to the unprocessed group:


  • Fage Greek yogurt parfait with strawberries, bananas, walnuts, salt, and olive oil
  • Apple slices with freshly squeezed lemon

Now, compare it to this breakfast for the ultraprocessed group:


  • Honey Nut Cheerios
  • Whole milk with NutriSource fiber
  • Packaged blueberry muffin
  • Margarine

Sure, it's less healthy than the unprocessed breakfast, but it's not like they were eating Froot Loops. (You can read the full meal plan for each diet online.)

The takeaway here is a simple one: ultraprocessed foods, even the ones that don't seem as bad, can and do contribute to weight gain if you make them a regular part of your diet. The good news is that the swaps can be simple — fruit and yogurt for cereal — and just as satisfying and delicious, if not more so. This two-week clean-eating guide, made up of all whole foods and tasty homemade recipes, is tailor-made to help you avoid those extra calories and head for a healthier lifestyle.