Stain remover pens like Tide To Go ($6) can help with spot blotting, but if you need to clean a heavier stain, pack a tiny bit of powdered detergent in an extra plastic bottle (like an emptied, rinsed, and dried hotel sample size). It's a lot cheaper than buying a jug or box of detergent on vacation when you'll only use a tiny bit to hand-wash something.
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