For all you Mac users, I have quite the hotkey tip if you're not already using it. Quicksilver for Macs is a quick way to open up applications and documents just by using your keyboard. More than just an application launcher, you can also move and delete files within Quicksilver.
Here's how it works: Download the program from Blacktree.com and once installed, launch the program and set the hotkeys to a combination that's easy for you remember (for example, I use Apple plus spacebar). Use this hotkey and then start typing the name of the application or document that you want to open, and it shows up on your screen. Press enter to open, and there you are!