Hotel rooms are small, and fitting family in there, with all their stuff, can really get chaotic if you don't keep on top of the mess. Keeping your room clean will cut down on frustration, big-time. If you drove, you can even stow empty suitcases in your car to alleviate some clutter. And don't forget, stepping on Legos in the middle of the night in a hotel room doesn't hurt any less.
Source: Flickr user rafael-castillo