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Water can deactivate the perm cream if it makes contact with your lashes too soon, so avoid getting them wet for at least three hours. I chose to wait until the next morning just to be safe — which is the recommended time frame for applying mascara, anyways. Because these are your natural lashes, you won't have to worry about sticking to water-based mascaras, routinely combing through them with a spoolie, or anything else you'd have to do with lash extensions. Using your favorite mascara is both welcomed and encouraged.