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Depo-Provera, a hormonal injection, is approximately 99 percent effective when used properly — which means getting a shot every 12 weeks. One of the benefits of Depo-Provera is not having to take a daily pill, but a common side effect includes irregular bleeding, which can occur for the first six to 12 months of use. Because the shot does not contain estrogen, it is considered a good option for breastfeeding mothers, but because it is long-lasting, if you're looking to get pregnant within six to 10 months of going off the method, it may not be the best option for you.