Tucked in the Eastern corner of France, Alsace-Lorraine might just be the country's most charming region. The brightly colored houses and floral-lined canals are fresh out of the pages of a fairy tale, and towns like Colmar, Strasbourg, and Riquewihr will likely inspire you to burst into song, Beauty and the Beast style (or is that just me?).
It takes around four and a half to five hours (by train or car) to get to Colmar from Grenoble, but it's well worth another long trip. Be sure to try the tarte flambée at La Fleur de Sel as well — it's a local specialty.