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Ah, tequila. First produced by the Spanish conquistadors in the 16th century as a replacement for brandy, the agave-based liquor comes primarily from the Mexican state of Jalisco. "This region outside of Guadalajara should be stop numero uno for anyone looking to delve deeper into the world of Mexico's favorite spirit," says Balboni.
One of the easiest ways to experience "tequila country" is aboard one of the tequila-themed trains that run from Guadalajara. The Tequila Express will take you to the town of Amatitán, home of the Herradura distillery, while the Jose Cuervo Express takes you to the town of Tequila and the Cuervo distillery. Can't imagine a trip to Mexico without the beach? "Puerto Vallarta on the Pacific coast is about five and a half hours from Guadalajara by car," says Balboni.