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Niacinamide, which is a topical B3 vitamin, is becoming a popular ingredient for not only its antiaging properties but also its ability to reduce the appearance of blemishes. "Sebum reduction is crucial to addressing acne as excess oil creates an environment in which bacteria can thrive, leading to breakouts and irritation," Dr. Murad said. If you suffer from postinflammatory hyperpigmentation, niacinamide can also help: "It evens skin tone, helping to prevent discoloration that can be left behind after active acne has subsided," he said.