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This myth has stood the test of time, but Dr. Lee says it's not ideal — and may not even work in most cases depending on the ingredients of the toothpaste. While it's true that toothpaste might help dry out your pimple, it can also leave you with dry, irritated, flaky, and peeling red skin. "I'd much rather people spot treat with a salicylic acid or benzoyl peroxide treatment," she said.