See Julia Roberts's Smiliest Moments

Julia Roberts has always been known for her megawatt smile and infectious laugh. Over the years, the 51-year-old actress and activist has shared sweet and smiley moments with husband Danny Moder and children Henry, Phinneas, and Hazel, as well as her many A-list costars. In honor of her iconic pearly whites, look ahead to see all of her happiest moments!

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Julia and her husband Danny Moder took the stage during a fundraiser for Heal the Bay in Santa Monica in May 2012.

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She and niece Emma laughed it up on the red carpet during the Valentine's Day premiere in 2010.

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At the Academy Awards Governors Ball in 2004, Julia got a kick out of her own photos.

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Remember when Julia appeared on an episode of Friends? Here she is flashing her signature smile with Matthew Perry in 1996.

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Julia flashed her famous smile with George Clooney and Giorgio Armani at the Costume Institute Gala in 2008.

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Julia grinned from ear to ear at Spike TV's Guys Choice Awards in 2016.

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Julia was like a ray of light while walking around NYC in 2018.

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Julia smiled on the red carpet with her August: Osage County costar Meryl Streep at the film's LA premiere in December 2013.

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Julia and her pearly whites made a guest appearance on SiriusXM's The Jess Cagle Show in 2019.

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Julia beamed on the SAG Awards red carpet in January 2015.

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Julia was all smiles with her husband, Danny Moder, and their three kids as they joined surfer Kelly Slater for a charity event in August 2015.

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Julia and Richard Gere stole warm glances while at an Amnesty International event in 1998.

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She smiled in a black and white striped suit at the New York Film Festival in 1993 with then-husband Lyle Lovett.

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Julia and Michael Sheen had matching smiles at an LA event in April 2012.

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She couldn't contain her excitement after being honored with a Hollywood Film Award in October 2013.

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She and then-boyfriend Benjamin Bratt looked lovingly into each other's eyes at the 1999 premiere of The Runaway Bride.

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Julia and her Larry Crowne costar Tom Hanks smiled for the cameras at an awards ceremony in February.

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Julia and George Clooney were very smiley during Money Monster's photocall at the 2016 Cannes Film Festival.

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She and Jennifer Aniston cracked each other up at the SAG Awards in January 2015.

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In 2017, Julia and her famous smile dazzled at a press conference for the film Wonder.

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She was all smiles with her August: Osage County costar Julianne Nicholson at the film's Toronto International Film Festival premiere in September 2013.

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She shared a laugh with George Clooney at the 2001 premiere of Ocean's Eleven.

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Julia enjoyed a good laugh with other attendees at the 2019 Oscars.

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Julia posed with a fresh-faced Natalie Portman at the American Cinematheque Awards in 2007.

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She couldn't stop smiling at the 2014 Emmy Awards.

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Her grin couldn't be contained after she won the Best Actress Academy Award for her role in Erin Brockovich; she posed backstage with an equally smiley Russell Crowe in 2001.

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Julia shared a giggle with pal Gwyneth Paltrow at a charity event in 2001.

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She and her My Best Friend's Wedding costar Cameron Diaz got cheeky at the Golden Globes in 2000.

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Julia got a laugh out of Denzel Washington after he won an Oscar for Best Actor at the 2002 Academy Awards.

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Julia laughed even while sporting heavy eyeshadow and a feathered haircut at a movie premiere with brother Eric and actor Jon Voight.

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Julia giggled with Andy Garcia at the Showest Convention in 1991.

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She and Kerry Washington posed for an adorable snap at the SAG Awards in January 2014.

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She smiled and snuggled with then-fiancé Kiefer Sutherland at the Young Guns II premiere in 1990.

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Julia shared a sweet red-carpet moment with Benjamin Bratt at the Red Planet premiere in 2000.

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Julia happily paid tribute to Denzel Washington at the 2019 AFI Life Achievement Award gala.

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Julia laughed with Oprah Winfrey at the 2005 Academy Awards Governors Ball.

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She was even able to crack up Clint Eastwood at the ShoWest convention in 1993.

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Julia and Olympic gymnast Gabby Douglas smiled backstage at an LA Stand Up to Cancer event in September 2012.

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The actress reunited with her My Best Friend's Wedding costar Dermot Mulroney at the Hollywood Film Awards in October 2013.

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She posed with pal Mel Gibson at the Conspiracy Theory premiere in 1997.

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In 2019, Julia showed her support for the Sean Penn CORE Gala and its efforts to raise money for Haiti and other communities.

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Catherine Zeta-Jones squeezed into a photo with Julia while at an America's Sweethearts premiere in 2001.

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Julia lit up the red carpet at Homecoming's TIFF premiere in 2018.

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She posed with Dermot Mulroney at the October 2011 premiere of Fireflies in the Garden in LA.

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In 2019, Julia and Bradley Cooper buddied up for a sweet photo op at the Critics' Choice Awards.

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A suit-wearing Julia grinned after winning a Golden Globe in 1990.

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Julia and her Mona Lisa Smile costar Ginnifer Goodwin shared a smile at the movie's premiere in 2003.

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She gave Jon Bon Jovi a squeeze at the Young Guns II premiere in July 1990.

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Julia looked delighted while promoting Ben Is Back at the 2018 TIFF event.

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Julia posed backstage at the Rainforest Foundation Benefit Concert in 1997 with Sting and his wife Trudie Styler.

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Julia smiled with Muhammad Ali at an Amnesty International party in 1998.

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In 2019, Julia honored Rita Wilson at the Sleepless in Seattle star's Hollywood Walk of Fame ceremony.

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She flashed her pearly whites with Cameron Diaz at the premiere party for My Best Friend's Wedding in 1997.

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Julia and actor Rupert Everett were a match at the Blockbuster Awards in 1998.

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At the 2017 amfAR Gala, Julia gave a big grin while speaking on stage.

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She helped honor friend George Clooney with an American Cinematheque Award in 2006.

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Julia joked with Garry Marshall and Bradley Cooper at the premiere of Valentine's Day in 2010.

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She and her Stepmom costar Susan Sarandon sat side by side at the Todd Oldham Fashion Show in 1995.

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Julia and Javier Bardem shared a laugh in Spain while attending the San Sebastian Film Festival in 2010.

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A fresh-faced Julia hung out with Harrison Ford at ShoWest in 1993.

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Julia was pretty in pink as she twinkled at the 2017 Calzedonia Legs Show.