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In 2019, Kutcher dealt with a rare form of the autoimmune disease vasculitis. He opened up about the experience in the 2022 docuseries "The Checkup With Dr. David Agus," where he revealed that at one point, he couldn't walk due to hearing issues affecting his equilibrium and his vision was impaired. Dr. Agus noted in the series that it was beautiful to see how Kunis curled up beside her husband and offered him support throughout his recovery.
Kunis later told Entertainment Tonight how she and Kutcher dealt with him being so unwell. "I don't think you have time to sit down and talk, you kinda just power through," she said. "You go and deal with whatever health issue comes your way, but you still got kids, you still got a family, you have to live life. And I think that we are so fortunate to have one another, but as far as sitting there and incessantly talking about things, no. You gotta do."