Schumer's father really has MS.
Colin Quinn plays Gordon, Amy's dad, in the film. Not only is Schumer's real father actually named Gordon, but like the character he inspired, he also has multiple sclerosis. Schumer has spoken about his disease in her stand-up act, joking that despite being in a wheelchair, he still thinks he's God's gift to the world. She's also used her popularity to bring awareness to MS and has donated part of the profits from Trainwreck's comedy tour to the National Multiple Sclerosis Society.