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It's obviously impressive when female directors have had more than one high-grossing film — especially when they seem to go unnoticed. Case in point is Betty Thomas, who directed Alvin and the Chipmunks: The Squeakquel, which brought in a whopping $443.1 million. Her second major hit was Doctor Dolittle in 1998 at $294.4 million. Thomas has had high-grossing films in both the animated and live-action categories, proving she can do just about anything when it comes to making movies.