Miles Morales may be the most obvious choice to pass along the Spidey mantle to, but he's not the only choice. If we're taking Into the Spider-Verse as a potential model, we could be on track not for a new Spider-Man, but a Spider-Woman! In one storyline from Marvel comics and in the animated Spider-Verse, one alternate universe has Gwen Stacy becoming a superhero after being bitten by a radioactive spider, just like Peter Parker does in the "classic" Spider-Man storyline.
Spider-Woman isn't just a title for Gwen's alternate self, though. Throughout the history of Marvel comics, several women have had the title, and any one of them could theoretically be introduced in Spider-Man 4, especially if it's leading towards Peter retiring from super-heroics.
