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While her character, Monica Geller, was struggling with her fertility on "Friends," Courteney Cox was experiencing the same hardships in real life. Before giving birth to daughter Coco, she and then-husband David Arquette experienced multiple pregnancy losses and rounds of IVF. She opened up about the experience during an episode of "Busy Tonight" with Busy Philipps, per USA Today.
"I had a lot of miscarriages and I don't think that's something people shouldn't talk about because it's . . . unfortunate, but it happens."