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While some dogs may be extra clingy, some prefer isolation when depressed. If they avoid social contact, whether with humans or other animals in the house, when they've always loved being around others, that's a red flag, says Erin Askeland, CBCC-KA, CPDT-KA of Camp Bow Wow. After speaking to a vet and ruling out medical issues, try and bring some fun back into their lives, like fresh air or a new type of treat, she suggests, to ease them back into better spirits.