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A 1985 appearance in Seventeen shot this Pennsylvania teen to model stardom, leading to campaigns like Escada, and over 50 magazine covers, including Vogue Italia. She was a favorite of top photographers like Herb Ritts and Steven Meisel, and in 1989 she also appeared in the music video for New Order's "Round and Round," cementing her status as an It model.
She divorced singer John Mellencamp in 2011 and has since married auto heir Jay Penske. Most recently, Irwin shot a Swimsuits for All campaign with Ashley Graham.