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Refrigerating butter is a bit of a debate, but here's the best practice. Unsalted butter is best left in the fridge at all times, but salted butter is less prone to bacterial growth because of its sodium content, so it can be kept out of the fridge (in a butter crock or airtight container) for about two weeks. If room temperature in your kitchen reaches above 70°F, however, it's best to refrigerate ASAP.