5 Smart Real Girls That You Should Know About

The young founder and CEO of Theranos has a net worth of $4.5 billion and is the youngest self-made female billionaire. After her uncle's death from cancer, she was determined to develop a way to detect diseases earlier. She dropped out of Stanford and made it happen. Holmes' developments only require a few drops of blood to use for running multiple tests at a much lower cost than commercial labs.

This CEO and Co-founder of SOLS, brings 3D printing to footwear that is helping the world walk better. Having worn orthotics as a child, Schouwenburg was interested in experimenting with 3D printing and knew the possibilities were there to do something amazing. SOLS works through a digital process that takes six photos of your foot then uses the measurements to create the perfect pair of orthotics.

Most of us are familiar with Blake Lively as a talented actor, but she's so much more. The entrepreneur put her lifestyle business dreams on hold when Gossip Girl came along, but she's strongly moving forward with Preserve. And Blake's involved with every aspect from the photography to raising capital.

The beauty and makeup entrepreneur shared her first online tutorial in 2007 and things went viral from there. With over 8 million YouTube subscribers, Michelle Phan was recently signed by Lancôme as their first video makeup artist. Phan also created her own makeup line for L'Oreal and founded the sampling beauty-box subscription service, Ipsy, which is valued at over $500 million.