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Differin Adapalene 0.1% Acne Treatment Gel ($26, originally $33)

Tackle breakouts and acne with this trusted, prescription-strength retinoid. Whether you want to stock up your stash or want to venture into retinoids, this is worth every penny.

"While I still went through an adjustment period as my skin got used to the powerful vitamin A derivative — which usually causes some purging, dryness, flakiness, or slight redness — it was much more tolerable for me. The gel texture is very lightweight, and a little bit (about a pea size) is easily blended onto my entire face," says one of our editors. Read more in her Differin review here.