Taking a step into the magical city of Cartagena, you'll immediately see why the city is a must-visit destination for you and your girlfriends. The colorful homes only rival the bougainvilleas dripping from rooftops, the azure waves of the sea, and bright plazas drenched with unrelenting Caribbean sun. The energy of the Caribbean city is palpable, and its size is totally doable for a long girls' weekend, even though there's always more to discover in Cartagena. Stay at Casa San Agustin, an old restored convent dating back to the 17th century. Some rooms have private gardens and pools for when you and your friends just want to take it easy and sip limonadas.