Season 2 of "Grey's Anatomy": "Chasing Cars" by Snow Patrol

Of all the memorable musical moments on "Grey's Anatomy," we dare you to find one more emotional and iconic than this track. "Chasing Cars" by Snow Patrol can be heard playing over the devastating final scene of season two. After what seems to have been a successful (though dangerous) gambit to save Denny's life, Izzie arrives to show her new fiancée her "prom" gown, only to find him dead. At first, she's unwilling to leave him, but eventually, she allows Alex to carry her away. This track plays as Izzie mourns her loss.

It's also worth noting that this song pops back up in later seasons. It makes a reappearance in season seven's (in)famous musical episode, and it also plays over the scene in season 11 when Meredith returns home, following Derek's death and the birth of their youngest daughter, Ellis.