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Salicylic acid, the other most common OTC acne-fighting ingredient, is a beta hydroxy acid (aka BHA). This chemical exfoliant works by breaking down dirt or oil in your pores. "This is helpful as a spot treatment, wash, or lotion for reducing whiteheads and blackheads, which are caused by plugs of skin cells in a pore," Dr. Rao explained. She also noted that salicylic acid can be used in higher concentrations as a chemical peel in your dermatologist's office.