Julia Roberts and George Clooney have been as thick as thieves since starring in Ocean's Eleven together in 2001. (Sorry, we couldn't resist.) Since then, the two friends have hit many red carpets, appeared in three other movies together, and even caught a ride in Gwen Stefani's Carpool Karaoke — but no matter the occasion, Julia and George always seem to be absolutely losing their sh*t and cracking up whenever they're reunited. What's more, Julia is a fan of George's wife, Amal Clooney, with whom he welcomed twins in 2017. "George doesn't need my approval," Julia told People, "but I am quite enamored of her." Ahead, see the sweetest pictures to come out of this high-profile friendship.