See Julia Roberts's Smiliest Moments

Julia and her husband Danny Moder took the stage during a fundraiser for Heal the Bay in Santa Monica in May 2012.

She and niece Emma laughed it up on the red carpet during the Valentine's Day premiere in 2010.

At the Academy Awards Governors Ball in 2004, Julia got a kick out of her own photos.

Remember when Julia appeared on an episode of Friends? Here she is flashing her signature smile with Matthew Perry in 1996.

Julia flashed her famous smile with George Clooney and Giorgio Armani at the Costume Institute Gala in 2008.

Julia grinned from ear to ear at Spike TV's Guys Choice Awards in 2016.

Julia's infectious smile shone through during an LA event in 2014.

Julia was like a ray of light while walking around NYC in 2018.

Julia smiled on the red carpet with her August: Osage County costar Meryl Streep at the film's LA premiere in December 2013.

Julia and her pearly whites made a guest appearance on SiriusXM's The Jess Cagle Show in 2019.

Julia beamed on the SAG Awards red carpet in January 2015.

Julia was all smiles with her husband, Danny Moder, and their three kids as they joined surfer Kelly Slater for a charity event in August 2015.

Julia and Richard Gere stole warm glances while at an Amnesty International event in 1998.

She smiled in a black and white striped suit at the New York Film Festival in 1993 with then-husband Lyle Lovett.

Julia and Michael Sheen had matching smiles at an LA event in April 2012.

She couldn't contain her excitement after being honored with a Hollywood Film Award in October 2013.

She and then-boyfriend Benjamin Bratt looked lovingly into each other's eyes at the 1999 premiere of The Runaway Bride.

Julia and her Larry Crowne costar Tom Hanks smiled for the cameras at an awards ceremony in February.

Julia and George Clooney were very smiley during Money Monster's photocall at the 2016 Cannes Film Festival.

She and Jennifer Aniston cracked each other up at the SAG Awards in January 2015.

Julia showed her megawatt smile after winning a Golden Globe in 2001.

In 2017, Julia and her famous smile dazzled at a press conference for the film Wonder.

She was all smiles with her August: Osage County costar Julianne Nicholson at the film's Toronto International Film Festival premiere in September 2013.

She shared a laugh with George Clooney at the 2001 premiere of Ocean's Eleven.

Julia enjoyed a good laugh with other attendees at the 2019 Oscars.

Julia posed with a fresh-faced Natalie Portman at the American Cinematheque Awards in 2007.

She couldn't stop smiling at the 2014 Emmy Awards.

At the 2018 NYC premiere of Ben Is Back, Julia struck a cheerful pose while cameras flashed.

Her grin couldn't be contained after she won the Best Actress Academy Award for her role in Erin Brockovich; she posed backstage with an equally smiley Russell Crowe in 2001.

Julia shared a giggle with pal Gwyneth Paltrow at a charity event in 2001.

She and her My Best Friend's Wedding costar Cameron Diaz got cheeky at the Golden Globes in 2000.

Julia got a laugh out of Denzel Washington after he won an Oscar for Best Actor at the 2002 Academy Awards.

Julia laughed even while sporting heavy eyeshadow and a feathered haircut at a movie premiere with brother Eric and actor Jon Voight.

Julia giggled with Andy Garcia at the Showest Convention in 1991.

Julia put the "gold" in Golden Globe Awards at the 2019 ceremony.

She and Kerry Washington posed for an adorable snap at the SAG Awards in January 2014.

She smiled and snuggled with then-fiancé Kiefer Sutherland at the Young Guns II premiere in 1990.

Julia shared a sweet red-carpet moment with Benjamin Bratt at the Red Planet premiere in 2000.

Julia happily paid tribute to Denzel Washington at the 2019 AFI Life Achievement Award gala.

Julia laughed with Oprah Winfrey at the 2005 Academy Awards Governors Ball.

She was even able to crack up Clint Eastwood at the ShoWest convention in 1993.

In 2016, the actress shared an infectious laugh at the GLSEN Respect Awards.

Julia and Olympic gymnast Gabby Douglas smiled backstage at an LA Stand Up to Cancer event in September 2012.

The actress reunited with her My Best Friend's Wedding costar Dermot Mulroney at the Hollywood Film Awards in October 2013.

She posed with pal Mel Gibson at the Conspiracy Theory premiere in 1997.

In 2019, Julia showed her support for the Sean Penn CORE Gala and its efforts to raise money for Haiti and other communities.

Catherine Zeta-Jones squeezed into a photo with Julia while at an America's Sweethearts premiere in 2001.

Julia lit up the red carpet at Homecoming's TIFF premiere in 2018.

Brad Pitt gave Julia his seal of approval at the premiere of The Mexican in 2001.

She posed with Dermot Mulroney at the October 2011 premiere of Fireflies in the Garden in LA.

In 2019, Julia and Bradley Cooper buddied up for a sweet photo op at the Critics' Choice Awards.

A suit-wearing Julia grinned after winning a Golden Globe in 1990.

Julia and her Mona Lisa Smile costar Ginnifer Goodwin shared a smile at the movie's premiere in 2003.

She gave Jon Bon Jovi a squeeze at the Young Guns II premiere in July 1990.

Julia looked delighted while promoting Ben Is Back at the 2018 TIFF event.

She smiled in a bubblegum-pink dress at the premiere of Stepmom in 1998 with then-boyfriend Benjamin Bratt.

Julia posed backstage at the Rainforest Foundation Benefit Concert in 1997 with Sting and his wife Trudie Styler.

Julia smiled with Muhammad Ali at an Amnesty International party in 1998.

In 2019, Julia honored Rita Wilson at the Sleepless in Seattle star's Hollywood Walk of Fame ceremony.

She flashed her pearly whites with Cameron Diaz at the premiere party for My Best Friend's Wedding in 1997.

Julia and actor Rupert Everett were a match at the Blockbuster Awards in 1998.

At the 2017 amfAR Gala, Julia gave a big grin while speaking on stage.

Julia reunited with her Steel Magnolias costar Sally Field at the American Cinematheque Awards in 2007.

She helped honor friend George Clooney with an American Cinematheque Award in 2006.

Julia joked with Garry Marshall and Bradley Cooper at the premiere of Valentine's Day in 2010.

She and her Stepmom costar Susan Sarandon sat side by side at the Todd Oldham Fashion Show in 1995.

Julia and Javier Bardem shared a laugh in Spain while attending the San Sebastian Film Festival in 2010.

A fresh-faced Julia hung out with Harrison Ford at ShoWest in 1993.

Julia was pretty in pink as she twinkled at the 2017 Calzedonia Legs Show.