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Katie Gaffigan was born on May 10, 2009. Before she was born, Jim and Jeannie had a pregnancy loss in April 2008. Touching on her birth, Jeannie revealed to Catholic New York, "I think the Blessed Mother was showing me that through great pain, in a very literal way, comes a beautiful gift from God."
Like her other siblings, Katie has inherited her parents' sense of humor, with Jeannie writing in a celebratory birthday post on Instagram in 2021, "Katie is sunshine & starlight & fills the room with magic. Keep making us smile & being silly when you're serious & serious when you're silly."