"Chasing Cars" by Snow Patrol
- When it destroyed you: Season two, episode 27
- Why it destroyed you: An hour after Denny proposes to Izzie, he dies from an unforseen blood clot. Izzie, devastated, has to be forcibly removed from his dead body and tells Bailey and Webber that she's quitting. It's one of the most iconically tragic moments of the entire show.