"Keep Breathing" by Ingrid Michaelson
- When it destroyed you: Season three, episode 25
- Why it destroyed you: On the day of the wedding she wasn't even really sure she wanted, Cristina is left at the altar by Burke. While standing in her living room in her wedding dress afterward, she has a total meltdown and screams at Meredith to cut her out of her gown. The scene might have come across as a little cheesy, but with a phenomenal actress like Sandra Oh at the helm, it's brutally perfect.