The Most Heartbreaking Character Exits on Grey's Anatomy, Ranked

After twelve seasons, Callie eventually departs Seattle for New York when her girlfriend at the time gets a prestigious grant. It's not necessarily sad that she's leaving for a new opportunity, but it's very sad how the resulting custody battle causes enormous pain for her, Arizona, and their daughter Sofia. Fortunately, the bittersweet ending for Callie's time on the show has a relatively happy outcome, as Arizona eventually leaves Seattle too, joining Callie in New York, where it's hinted they're trying to rebuild their family.