The Most Heartbreaking Character Exits on Grey's Anatomy, Ranked

One of the saddest deaths on Grey's is the death of a character who lived only briefly. April and Jackson find out that they're going to have a baby, but their joy turns to grief when they learn that their son has a rare bone disease that is incompatible with life. April is induced early, and she and Jackson are able to name their son Samuel and hold him for the few minutes of his life. It's a completely devastating tragedy that is incredibly difficult to watch.