Let's talk about one of the most controversial exits in Grey's history, shall we? When actor Justin Chambers left the show suddenly, Alex had to leave too, but how? He disappeared after rallying Meredith's supporters for her licensing hearing, and eventually sent letters explaining why. While searching for supporters for Meredith, he tracked down Izzie, and he found out that she had their children with the eggs they'd frozen during Izzie's cancer battle. Alex then leaves his friends and his career — not to mention his wife Jo — to get back together with Izzie. While it's not a tragedy in the sense of killing off a character, it wasn't easy for many viewers to see Alex's character end this way after nearly 15 years of character development.
